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Kudo Shinichi is a seventeen year-old high school detective whom people call the "Modern Sherlock Holmes." However, one night after a date with his childhood sweetheart, Ran, Shinichi witnessed an illegal trade and, caught off his guard, was knocked unconscious and fed a drug that was supposed to kill him... but he woke up and found himself shrunken to a seven year-old. In order to track down the men who did this to him, Shinichi hid his identity and lived with Ran, whose father happened to be a hopeless detective, and with that came a series of murders and mysteries that he must solve.

After one of his coworkers fails to repay a debt, apathetic bum Kaiji Itou is pressured by loan sharks to settle the large sum of cash. Since Kaiji has little money and no future prospects of his own, he is unable to return what his colleague borrowed. Faced with massive financial burdens, Kaiji is given an offer to board the illustrious Espoir—it is said that "one night aboard the ship, and all of your debts will be paid." What seems like a simple night of gambling quickly turns into a game of strategy and betrayal. With the losers of the tournament being subjected to a backbreaking life of indebted servitude, Kaiji must choose his actions—and allies—carefully. However, this is only the beginning of a series of gambles that will wager Kaiji's life, testing the full extent of his wits and will to survive.

A newspaper article about a vandalized painting catches the eye of William James Moriarty. Recognizing the artist from his childhood days in the slums, he takes his brother Louis with him on a trip to the city of Bath to meet with the artist personally and identify the culprit. However, the person claiming to be the painter is not the man William remembers. Joined by Sherlock Holmes and John H. Watson, William looks for clues in order to find his old friend.

One day, college student Yuuhi Amamiya is approached by talking lizard Sir Noi Crezant. Crezant immediately launches into a fantastical story: the powerful mage Animus intends to destroy the earth with his biscuit hammer, a huge contraption looming high in earth's orbit. Earth's only hope lies with the princess and her Beast Knights, whose task is to protect the princess and defeat Animus. Yuuhi is chosen as the Lizard Beast Knight, and despite his misgivings, is quickly forced to defend himself from a golem created by the mage. He is saved by his neighbor, the princess Asahina Samidare, and swears loyalty to her. However, the princess does not intend to save the earth at all. She lets Yuuhi in on her real motivations: to prevent Animus from destroying the earth, only to then annihilate the planet by her own hand. The pair continue to fight off attacks by Animus's golems while the remaining Beast Knights are slowly being gathered and learning to use their powers. But Yuuhi will have to decide for himself whether to go along with Asahina's plans, whom he is getting close to, or to save the earth. In the process, he must also confront his true self, and determine where his loyalties truly lie.