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The adventures of a whiny teenage Miyamoto Musashi, his electro-sword and demon-sealing revolvers, and his quest to win the love of the beautiful Kaguyahime.

During the turbulent end of the Tokugawa era, many children became war orphans. One of these orphans, a nameless son of a samurai, ends up meeting Ryouma Sakamoto, a man working against the Bakufu government. Impressed by the orphan's skill with a blade, Ryouma gives him the name "Ryo" and lets him travel by his side.

In 2030, Japan. A virus has infected humans throughout the world. Infected people turn into different forms of monsters based on their ages, sexes, and races. The virus is named "Gibia"—after being rich in variety like gibia. Just then, a pair of samurai and ninja appeared in such a blighted wasteland of Japan. They both traveled from the early Edo period, fighting together with help from a doctor who tries to find cure for Gibia. Facing ceaseless attacks from Gibias and outlaws that attack travelers for food, they start the dangerous journey with enemies all around.

Manji is an immortal swordsman, who has been cursed with eternal life. He has grown tired of living with all the death he has created. He has no skills other than those of killing, thus he forms a plan to regain his mortality: he shall kill one hundred evil men for each good one he has killed. The old witch who afflicted Manji with immortality agrees to Manji’s proposition and Manji is set on his path to kill one thousand evil men. On his journey he meets a young girl, Rin, who has her own vengeance to seek against the sword school whose members slaughtered Rin’s family. Rin and Manji journey together, each hoping to find some kind of peace. In their way are many varied enemies. Rin and Manji are almost constantly under attack and must learn to live their lives, avoiding being consumed by revenge.